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Recent News

  • Alert PyschNews(2017) Adjunctive Ketamine Appears to Reduce Suicidal Thoughts in Depressed Patients for Up to Six Weeks
  • CurrentPsychiatry.com (2016) The Future of Ketamine in Psychiatry
  • Psychology Today (2016) A New Medication on the Horizon for Depression
  • Neurology Advisor (2016) Ketamine May Be Effective in Major Depression
  • Psychiatry Advisor (2016) Ketamine May Provide Lasting Relief From Depression
  • Economist.com (2016) Novel drugs for depression
  • PRNewswire (2016) New Study Shows Ketamine May Regenerate Brain Cells, Relieving Depression with Lasting Benefit
  • New York Magazine (2016) What It’s Like to Have Your Severe Depression Treated With a Hallucinogenic Drug
  • J&J Press Release (2016) Esketamine Receives Breakthrough Therapy Designation from U.S. Food and Drug Administration for Major Depressive Disorder with Imminent Risk for Suicide
  • CNN.com (2016) Party Drug Ketamine Closer to Approval for Depression
  • Nature.com (2016) How Club Drug Ketamine Fights Depression
  • NPR.com (2015) Depression Treatments Inspired By Club Drug Move Ahead In Tests
  • Bloomberg (2015) The Ketamine Cure
  • NPR (2015) Club Drug Ketamine Gains Traction As A Treatment For Depression
  • Nature.com (2015) Rave drug holds promise for treating depression fast
  • VICE News (2015) I Used Ketamine to Treat My Depression
  • NY Times (2014) Special K, a Hallucinogen, Raises Hopes and Concerns as a Treatment for Depression
  • Scientific American (2013) Is Ketamine the Next Big Depression Drug?
  • Time (2013) ‘Club Drug’ Ketamine Lifts Depression in Hours
  • NPR.com (2012) Ketamine Relieves Depression By Restoring Brain Connections
  • PsychiatricNews.com (2012) Ketamine-Induced Optimism: New Hope for the Development of Rapid-Acting Antidepressants
  • TheAtlantic.com (2012) ‘The Biggest Breakthrough in Depression Research’ in 50 Years Is … Ketamine?
  • National Institutes of Mental Health (2010) Rapid Antidepressant Works by Boosting Brain’s Connections

Research & News

Literature on Therapy for Depression

  • Arunogiri S, Keks NA, Hope J. Should ketamine be used for the clinical treatment of depression? Australas Psychiatry. Aug 2016;24(4):381-384.
  • Bobo WV, Voort JL, Croarkin PE, Leung JG, Tye SJ, Frye MA. Ketamine for Treatment-Resistant Unipolar and Bipolar Major Depression: Critical Review and Implications for Clinical Practice. Depress Anxiety. Apr 6 2016.
  • Caddy C, Amit BH, McCloud TL, et al. Ketamine and other glutamate receptor modulators for depression in adults. Cochrane Database Syst Rev. 2015(9):CD011612.
  • Fond G, Loundou A, Rabu C, et al. Ketamine administration in depressive disorders: a systematic review and meta-analysis. Psychopharmacology (Berl). Sep 2014;231(18):3663-3676.
  • Hasselmann HW. Ketamine as antidepressant? Current state and future perspectives. Curr Neuropharmacol. Jan 2014;12(1):57-70.
  • Henderson TA. Practical application of the neuroregenerative properties of ketamine: real world treatment experience. Neural Regen Res. Feb 2016;11(2):195-200.
  • Lapidus KA, Levitch CF, Perez AM, et al. A randomized controlled trial of intranasal ketamine in major depressive disorder. Biol Psychiatry. Dec 15 2014;76(12):970-976.
  • Messer M, Hailer I. Maintenance ketamine treatment produces long-term recovery from depression. Primary Psychiatry. May 21, 2013.
  • McGirr A, Berlim MT, Bond DJ, Fleck MP, Yatham LN, Lam RW. A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. Psychol Med. Mar 2015;45(4):693-704.
  • Murrough JW, Iosifescu DV, Chang LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. Oct 2013;170(10):1134-1142.
  • Newport DJ, Carpenter LL, McDonald WM, et al. Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression. Am J Psychiatry. Oct 2015;172(10):950-966.
  • Niciu MJ, Luckenbaugh DA, Ionescu DF, et al. Clinical predictors of ketamine response in treatment-resistant major depression. J Clin Psychiatry. May 2014;75(5):e417-423.
  • Rasmussen KG, Lineberry TW, Galardy CW, et al. Serial infusions of low-dose ketamine for major depression. J Psychopharmacol. May 2013;27(5):444-450.
  • Singh JB, Fedgchin M, Daly EJ, et al. A double-blind, randomized, placebo-controlled, dose-frequency study of intravenous ketamine in patients with treatment-resistant depression. Am J Psychiatry. Apr 8 2016:appiajp201616010037.
  • Solovitch S. Onetime party drug hailed as miracle for treating severe depression. The Washington Post. 2016.
  • Stiles, L. Ketamine may provide lasting relief from depression. Psychiatry Advisor. March, 24 2016.

Literature on Therapy for Post Traumatic Stress Disorder

  • Cassels, C. Ketamine: New potential as rapid PTSD treatment not just for depression anymore? Medscape Medical News. April 17 2014. (Free Medscape login required)
  • Canadian Agency for Drugs and Technologies in Health. Intravenous Ketamine for the Treatment of Mental Health Disorders: A Review of Clinical Effectiveness and Guidelines. Ottawa (ON). Aug 20 2014.
  • Feder A, et al. Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder, JAMA Psychiatry. 2014;71(6):681-688.
  • Womble, A. Effects of Ketamine on Major Depressive Disorder in a Patient with Posttraumatic Stress Disorder, AANA J. 2013;81(2):118-119.

Literature on Therapy for Chronic Pain

  • Birklein F, O'Neill D, Schlereth T. Complex regional pain syndrome: An optimistic perspective. Neurology. Jan 6 2015;84(1):89-96.
  • Connolly SB, Prager JP, Harden RN. A systematic review of ketamine for complex regional pain syndrome. Pain Med. May 2015;16(5):943-969.
  • Kim M, Cho S, Lee JH. The effects of long-term ketamine treatment on cognitive function in complex regional pain syndrome: A preliminary study. Pain Med. Aug 2016;17(8):1447-1451.
  • Niesters M, Martini C, Dahan A. Ketamine for chronic pain: risks and benefits. Br J Clin Pharmacol. Feb 2014;77(2):357-367.
  • O'Brien SL, Pangarkar S, Prager J. The use of ketamine in neuropathic pain. Curr Phys Med Rehabil Rep. 2014;2(2):128-145.
  • Puchalski P, Zyluk A. Results of the treatment of chronic, refractory CRPS with ketamine infusions: a preliminary report. Handchir Mikrochir Plast Chir. Jun 2016;48(3):143-147.
  • Sheehy KA, Muller EA, Lippold C, Nouraie M, Finkel JC, Quezado ZM. Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study. BMC Pediatr. 2015;15:198.
  • Xu J, Yang J, Lin P, Rosenquist E, Cheng J. Intravenous therapies for complex regional pain syndrome: A systematic review. Anesth Analg. Mar 2016;122(3):843-856.

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